Actress Jennifer Aniston poses during the 18th annual Gay and Lesbian Alliance Against Defamation (GLAAD) Media Awards at the Kodak theatre in Hollywood, California April 14, 2007.[Reuters] 

Aniston is in final talks to star in "He's Just Not That Into You," an ensemble comedy set to start shooting next month in Los Angeles.

The former "Friends" star will play a woman in a long-term relationship with a boyfriend who will not commit to marriage.

The New Line Cinema project, which weaves story arcs dealing with the challenges of reading or misreading human behavior, is based on the best-selling social commentary about modern-day relationships.

Already on board are Jennifer Connelly, Kevin Connolly, Bradley Cooper, Justin Long, Ginnifer Goodwin and Drew Barrymore, who will also produce. Ken Kwapis ("License To Wed") will direct.

Aniston most recently starred in Universal Pictures' hit comedy "The Break-Up."